Effect of Bioactive Compounds of Avocado (Persea Americana) Fruit Powder on Hypercholesterolemic Rats: Biological and Biochemical Studies

Amal N. Z.Nasef , Asmaa. H. Ahmed

This study was conducted to show the effect of different concentrations of avocado powder on some biological and biochemical parameters of hypercholesterolemic rats. Thirty male Sprague Dawley rats weighing between (180 ± 20g B.Wt) were divided into two main groups . The first main group (6 rats) was fed on basal diet as (control negative group –ve), while the second main group (24 rats) was classified into four groups (6 rats each) was fed on 1.5 % cholesterol plus 10% sheep tail for 15 days to induce hypercholesterolemia. One of these group was considered (control positive group +ve) and the other groups were  fed 10% ,15% and 25% avocado powder , respectively, for 28 days. The chemical composition and bioactive compounds of avocado fruit were determined. The biological parameters as (BWG, FER, and FI and weight of internal organs) determined and biochemical parameters as (lipid profile, liver function, kidney function) and histological examination of heart, liver and kidney were performed. The results indicated that there was a significant increase in lipid profile except HDL, liver function and kidney function in the control (+ve ) group . It can be noted that all treatments of avocado powder improved the previous parameters. The best treatment was observed in the group fed on 25% avocado powder.

Keywords: Avocado- Hypercholesterolemic–  biological, biochemical parameters-  lipid profile-  bioactive compounds.