The Effect of Metformin upon Spermatogenesis in Mice

Aalaa M. Ayyad and Mohamed A. El-Seehy

The effect of the drug Metformin has been studied, employing Mice genome ( mus musculus 2n=40) . Three doses 250, 500 and 1000 mg/ml in addition to the negative control were tested. The results obtained has now been reported for the first time; since a significant increases in sperms 10 fold-increases were obtained. It seems probable that such effect might be caused by enhancement of cell division.


Key words: Metformin, sperm, mice genome.