Effects of Camphor on Enzymes, Hormones and Liver Tissues of Male White Mice

Mohmed A.Desheesh, Abd Allah M.El-Shazly, Samir.T. El-Deeb and Rania H. El-Banna

The natural product Camphor was structurally confirmed by elemental analysis (C, H) and spectroscopic measurements (U.V, I.R and 1H-NMR). Camphor effects at sublethal doses (25, 50, 100 and 200 mg/kg) was tested on Plasma alanine amino-transferase (ALT), Aspartate amino-transferase (AST), Alkaline phosphatase  (ALPand Creatine Kinase (CK) blood enzymes;blood contents (WBC, RBC, Hg and HC); hormones (Testosterone and Follicle stimulating hormones (F.S.H) in addition to histopathological studies on liver tissues in male white mice.(Mus musculus var.albus

The results indicated that the higher doses (100 and 200mg/kg) of camphor highly elevated the activities of the tested enzymes where as the lower doses caused lower changes of activities, in comparison with control. The tested camphor reduced testosterone and induced FSH levels which may be caused adverse and lesion effects of male mice reproductive system. The results showed also that WBC counts in male mice increased with increasing the tested doses of camphor. Finally, all the tested doses of camphor caused harmful changes in liver tissues of the tested white male mice according to the histopathological studies, in comparison with control.

key words:Camphor,  ALT, AST, ALP, WBC, RBC, Hg, Hc, Testosterone, Follicle Stimulating Hormone, Histopathological Studies on Liver, White Male Mice (Mus musculus var.albus).