Antimicrobial Activities of Synthesized 3-Acetyl Coumarin and Benzo-4-Methyl Coumarin

Mohammed A.Desheesh, Saad R. El-Zemity, Ezzat A.Kadous, Magda M. Fahmy, Emad E. Tawfeek

3-Acetyl coumarin and Benzo-4-methyl coumarin were synthesized and confirmed for their chemical structures by their melting points; carbon and hydrogen analysis in addition to their spectroscopy measurements By U.V, I.R , H1-NMR and M.S. These two compounds were evaluated for their fungicidal activities against Alternaria solani and Fusarium oxysporum in comparison with mancozeb as standard fungicide using radial growth method. The bactericidal of the two compounds were determined against Erwinia amylovora and Ralstonia solanacearum in comparison with streptomycin using agar disk-diffusion method. The results indicated that the synthesized benzo-4methyl coumarin and 3-Acetyl coumarin have fungicidal and bactericidal activities but less than standard (mancozeb and streptomycin) respectively. It also was found that Benzo-4-methyl coumarin was more active against the tested fungi Alternaria solani and Fusarium oxysporum, and bacteria Erwinia amylovora and Ralstonia solanacearum than 3-acetyl coumarin. Key words: coumarin derivatives, Pechmann condensation, Fungicide, Bactericide.